Lainé, Dramane I.: search on Z-Library

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1

Design, Synthesis, and Structure−Activity Relationship of Tropane Muscarinic Acetylcholine Receptor Antagonists

Lainé, Dramane I., Wan, Zehong, Yan, Hongxing, Zhu, Chongjie, Xie, Haibo, Fu, Wei, Busch-Petersen, Jakob, Neipp, Christopher, Davis, Roderick, Widdowson, Katherine L.

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.07 MB

english, 2009

2

Design, synthesis and structure–activity relationship of N-substituted tropane muscarinic acetylcholine receptor antagonists

Dramane I. Lainé, Hongxing Yan, Haibo Xie, Roderick S. Davis, Jeremy Dufour, Katherine L. Widdowson, Michael R. Palovich, Zehong Wan, James J. Foley, Dulcie B. Schmidt, Gerald E. Hunsberger, Miriam Bu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 379 KB

english, 2012

3

Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity

Richard Angell, Nicola M. Aston, Paul Bamborough, Jacky B. Buckton, Stuart Cockerill, Suzanne J. deBoeck, Chris D. Edwards, Duncan S. Holmes, Katherine L. Jones, Dramane I. Laine, Shila Patel, Penny A

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 358 KB

english, 2008

4

Discovery of Novel Cyanamide-Based Inhibitors of Cathepsin C

Lainé, Dramane, Palovich, Michael, McCleland, Brent, Petitjean, Emilie, Delhom, Isabelle, Xie, Haibo, Deng, Jianghe, Lin, Guoliang, Davis, Roderick, Jolit, Anais, Nevins, Neysa, Zhao, Baoguang, Villa

Journal:

ACS Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 2.02 MB

english, 2011

5

Discovery of Novel 1-Azoniabicyclo[2.2.2]octane Muscarinic Acetylcholine Receptor Antagonists

Lainé, Dramane I., McCleland, Brent, Thomas, Sonia, Neipp, Christopher, Underwood, Brian, Dufour, Jeremy, Widdowson, Katherine L., Palovich, Michael R., Blaney, Frank E., Foley, James J., Webb, Edwar

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.11 MB

english, 2009

6

An Asymmetric Phase-Transfer Dihydroxylation Reaction.

Riaz A. Bhunnoo, Yulai Hu, Dramane I. Laine, Richard C. D. Brown

Journal:

Year:

2003

File:

PDF, 112 KB

2003

7

ChemInform Abstract: Dispiroketals in Synthesis. Part 24. Preparation and Use of Chiral 2,2′-Bis(triisopropylsilyloxymethyl)bi(dihydropyran)s as New Protecting and Resolving Agents for 1,2-Diols.

Dramane Laine, Morifumi Fujita, Steven V. Ley

Journal:

Year:

1999

File:

PDF, 36 KB

1999

8

ChemInform Abstract: Dispiroketals in Synthesis. Part 25. Further Reactions of Dispiroketal Protected Glycolate to Afford Optically Active 1,2,3,4-Tetraols.

Morifumi Fujita, Dramane Laine, Steven V. Ley

Journal:

Year:

1999

File:

PDF, 37 KB

1999

9

Indium

Lainé, Dramane

Journal:

Year:

1999

Language:

english

File:

PDF, 57 KB

english, 1999

10

Highly Diastereoselective Oxy-Michael Additions of Enantiopure δ-Lactol Anions to Nitroalkenes: Asymmetric Synthesis of 1,2-Amino Alcohols.

Nicola J. Adderley, David J. Buchanan, Darren J. Dixon, Dramane I. Laine

Journal:

Year:

2003

File:

PDF, 155 KB

2003

11

Discovery of novel 8-azoniabicyclo[3.2.1]octane carbamates as muscarinic acetylcholine receptor antagonists

Dramane I. Lainé, Haibo Xie, Noémie Buffet, James J. Foley, Peter Buckley, Edward F. Webb, Katherine L. Widdowson, Michael R. Palovich, Kristen E. Belmonte

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 113 KB

english, 2007

12

Dispiroketals in synthesis. Part 25.1 Further reactions of dispiroketal protected glycolate to afford optically active 1,2,3,4-tetraols

Fujita, Morifumi, Lainé, Dramane, Ley, Steven V.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1999

Language:

english

File:

PDF, 324 KB

english, 1999

13

Highly Diastereoselective Oxy-Michael Additions of Enantiopure δ-Lactol Anions to Nitroalkenes: Asymmetric Synthesis of 1,2-Amino Alcohols

Nicola J. Adderley, David J. Buchanan, Darren J. Dixon, Dramane I. Lainé

Journal:

Angewandte Chemie International Edition

Year:

2003

Language:

english

File:

PDF, 112 KB

english, 2003

14

An Asymmetric Phase-Transfer Dihydroxylation Reaction

Riaz A. Bhunnoo, Yulai Hu, Dramane I. Lainé, Richard C. D. Brown

Journal:

Angewandte Chemie International Edition

Year:

2002

Language:

english

File:

PDF, 57 KB

english, 2002

15

Discovery of (3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for the treatment of COPD

Zehong Wan, Dramane I. Laine, Hongxing Yan, Chongjie Zhu, Katherine L. Widdowson, Peter T. Buckley, Miriam Burman, James J. Foley, Henry M. Sarau, Dulcie B. Schmidt, Edward F. Webb, Kristen E. Belmont

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 388 KB

english, 2009

16

Short asymmetric syntheses of bioactive β-aryl ethanolamine derivatives via the highly diastereoselective delta lactol oxy-Michael addition

David J. Buchanan, Darren J. Dixon, Mark S. Scott, Dramane I. Lainé

Journal:

Tetrahedron: Asymmetry

Year:

2004

Language:

english

File:

PDF, 244 KB

english, 2004

17

Inhibitors of cathepsin C (dipeptidyl peptidase I)

Laine, Dramane I, Busch-Petersen, Jakob

Journal:

Expert Opinion on Therapeutic Patents

Year:

2010

Language:

english

File:

PDF, 395 KB

english, 2010

18

Btk Inhibitor RN983 Delivered by Dry Powder Nose-only Aerosol Inhalation Inhibits Bronchoconstriction and Pulmonary Inflammation in the Ovalbumin Allergic Mouse Model of Asthma

Phillips, Jonathan E., Renteria, Lorena, Burns, Lisa, Harris, Paul, Peng, Ruoqi, Bauer, Carla M.T., Laine, Dramane, Stevenson, Christopher S.

Journal:

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Year:

2016

Language:

english

File:

PDF, 444 KB

english, 2016

19

An Asymmetric Phase-Transfer Dihydroxylation Reaction

Riaz A. Bhunnoo, Yulai Hu, Dramane I. Lainé, Richard C. D. Brown

Journal:

Angewandte Chemie

Year:

2002

Language:

english

File:

PDF, 57 KB

english, 2002

20

Highly Diastereoselective Oxy-Michael Additions of Enantiopure δ-Lactol Anions to Nitroalkenes: Asymmetric Synthesis of 1,2-Amino Alcohols

Nicola J. Adderley, David J. Buchanan, Darren J. Dixon, Dramane I. Lainé

Journal:

Angewandte Chemie

Year:

2003

Language:

english

File:

PDF, 112 KB

english, 2003

21

Synthesis of the non-adjacent bis-THF core of cis-sylvaticin using a double oxidative cyclisation

Bhunnoo, Riaz A., Hobbs, Heather, Lainé, Dramane I., Light, Mark E., Brown, Richard C. D.

Journal:

Organic & Biomolecular Chemistry

Year:

2009

Language:

english

File:

PDF, 335 KB

english, 2009

22

Dispiroketals in synthesis. Part 24.1 Preparation and use of chiral 2,2′-bis(triisopropylsilyloxymethyl)bi(dihydropyran)s as new protecting and resolving agents for 1,2-diols

Lainé, Dramane, Fujita, Morifumi, Ley, Steven V.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1999

Language:

english

File:

PDF, 222 KB

english, 1999

23

Long-acting muscarinic antagonists for the treatment of chronic obstructive pulmonary disease

Lainé, Dramane I

Journal:

Expert Review of Clinical Pharmacology

Year:

2010

Language:

english

File:

PDF, 2.13 MB

english, 2010

24

Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes

Richard M. Angell, Tony D. Angell, Paul Bamborough, Mark J. Bamford, Chun-wa Chung, Stuart G. Cockerill, Stephen S. Flack, Katherine L. Jones, Dramane I. Laine, Timothy Longstaff, Steve Ludbrook, Rosa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 609 KB

english, 2008

25

Inhaled long-acting muscarinic antagonists in chronic obstructive pulmonary disease

Busch-Petersen, Jakob, Lainé, Dramane I

Journal:

Future Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 949 KB

english, 2011

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